hrp0094p1-106 | Adrenal B | ESPE2021

Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel Proteomic Signature

Nicolaides Nicolas C. , Makridakis Manousos , Stroggilos Rafael , Koniari Eleni , Papageorgiou Ifigeneia , Sertedaki Amalia , Zoidakis Jerome , Charmandari Evangelia ,

Background: Tissue sensitivity to glucocorticoids is characterized by significant inter-individual variation in terms of therapeutic response and susceptibility to several stress-related disorders. Proteomics approaches, combined with appropriate bioinformatics analysis, offer a comprehensive description of molecular phenotypes with clear links to human disease pathophysiology.Objective and Hypotheses: To investigate the usefulness of pl...